Retinol binding protein 4 (RBP4) concentration identifies V122I transthyretin cardiac amyloidosis
نویسندگان
چکیده
منابع مشابه
Macrophages are novel sites of expression and regulation of retinol binding protein-4 (RBP4).
Obesity is linked to a low-level chronic inflammatory state that may contribute to the development of associated metabolic complications. Retinol-binding protein 4 (RBP4) is an adipokine associated with parameters of obesity including insulin resistance indices, body mass index, waist circumference, lipid profile, and recently, with circulating inflammatory factors. Due to the infiltration of a...
متن کاملPressure-volume relationships in patients with transthyretin (ATTR) cardiac amyloidosis secondary to V122I mutations and wild-type transthyretin: Transthyretin Cardiac Amyloid Study (TRACS).
BACKGROUND ATTR cardiac amyloidosis can result from a mutated variant of transthyretin (eg, V122I) or wild-type variant (ATTRwt). We evaluated pressure-volume (PV) indices at baseline and over time to further characterize abnormal pump function in these subjects. METHODS AND RESULTS Twenty-nine subjects (18 with ATTRwt and 11 with ATTRm (V122I) had 2-dimensional echocardiograms with complete ...
متن کاملLiver retinol transporter and receptor for serum retinol-binding protein (RBP4).
Vitamin A (retinol) is absorbed in the small intestine, stored in liver, and secreted into circulation bound to serum retinol-binding protein (RBP4). Circulating retinol may be taken up by extrahepatic tissues or recycled back to liver multiple times before it is finally metabolized or degraded. Liver exhibits high affinity binding sites for RBP4, but specific receptors have not been identified...
متن کاملassociation of plasma retinol binding protein-4 (rbp4) and sonographic grading of fatty liver in obese iranian children
results rbp4 levels in obese children (19 482.9 ± 3 302.2 pg/ml) were higher than those found in the lean control group (14 295.68 ± 2 381.3 pg/ml) (p < 0.05). in the obese patients, rbp4 levels showed a significant correlation with the grade of fatty liver and bmi (p < 0.05). conclusions it was found that the level of rbp4 had a strong correlation with the severity of fatty liver. therefore, r...
متن کاملV122I TTR Cardiac Amyloidosis in Patients of African Descent
Cardiac amyloidosis is caused by the aggregation and deposition of misfolded proteins in the extracellular space of the myocardium. The heart is one of multiple organs that may be involved in systemic amyloidosis and is usually the main cause of significant morbidity and mortality. Transthyretin amyloidosis (ATTR), one of the most common forms of cardiac amyloidosis, is increasingly recognized ...
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ژورنال
عنوان ژورنال: Amyloid
سال: 2017
ISSN: 1350-6129,1744-2818
DOI: 10.1080/13506129.2017.1295371